Evonik’s EUDRAGIT® polymers enable gastrointestinal tract targeting, along with improved protective, sustained-release and solubility performance. Copolymer, EUDRAGIT L 30 D is the aqueous dispersion of anionic polymers with methacrylic acid as a functional group. Physical properties: It is a. Pellets were coated with Eudragit L 30 D using fluidized bed processor. Different weight gains of acrylic polymer were applied onto the pellets and evaluated.
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Drug turns brown when comes in contact with air due to oxidation of phenolic group in benzene moiety, therefore 0.
A burst effect has so far not been reported with multiparticulate systems. The packed bulk density was calculated as the quotient of the weight and volume sedimented. Or if you don’t have an account with us yet, then click here to register.
o30 The dispersion was stirred slowly to avoid the production of air bubbles. Similarly pellets were also prepared with varying amount of granulating liquid, higher granulating liquid content resulted in harder pellets that could be a factor in delaying dissolution behavior.
Subscribe to Premium Services Searches: A g of batch of pellets was placed in the fluid bed coater and pre warmed for 10 min prior to the spraying.
Following materials were used for the development of multiparticulate system: A peristalsis pump was used to deliver the coating dispersion to the spray nozzle. All the reagents and solvents used were of analytical grades. Size of the pellets was determined by sieve shaker analysis.
The multiparticulate formulation of sodium para aminosalicylate for oral administration was developed by extrusion spheronization technique. Ten percent aqueous solution of PEG 8.
Pellets | Extrusion/spheronization | Eudragit L 30 D55 | Fluidized Bed Coater | Enteric-coated
We advise that you only use the original value or one of its raw conversions in your calculations to minimize rounding error. The dry ingredients were combined and mixed in twin-shell blender for 20 min and then transferred to planetary mixture where the aqueous binder solution prepared with HPMC E5, was slowly added. Twenty grams of pellets were poured gradually through a funnel in to 50 ml graduated cylinder, tapped lightly on hard surface and the volume measured. To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below.
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Morphological characteristics of developed pellets were also investigated by scanning electron microscopy and found to be smooth and spherical. Microcrystalline cellulose was used as filler in concentration of The acrylic polymer coating suspensions were prepared by adding water to the commercially available Eudragit L30 D Coating was applied by fluidized bed coater under parameters listed in Table 2.
The percentage friability was calculated from the pellet weight before and after fluidization [ 8 ]. Hence it was decided to give a seal coat to protect the drug.
Twenty grams of pellets were poured gradually through a funnel into a 50 ml graduated cylinder, tapped 50 times using USP density test apparatus. Glcerylmonostearate dispersion in methylene chloride was used for this purpose and was prepared by adding the powder to the solvent.
The contents, results, and technical data from this site may not be reproduced either electronically, photographically or substantively without permission from MatWeb, LLC. Pellet size and size distribution was determined for coated pellets with different weight gain and it was found to be narrow in distribution fig. Users requiring more precise data for scientific or engineering calculations can click on the property value to see the original value as well as raw conversions to equivalent units.
An over coat was added to Sod PAS pellets that were coated with Eudragit L 30 D to prevent the sticking of the pellets during dissolution studies and storage.
Click here to view all the property values for this datasheet as they were originally entered into MatWeb. Developed system was found to be suitable for the delivery of Sod PAS in to intestinal region.
Evonik EUDRAGIT® L 30 D Copolymer
l03 It is a milky-white liquid of low viscosity with a faint characteristic odor. Acrylates Copolymer Information provided by Evonik. Bulk density was calculated as the quotient of the weight and volume of pellets.
Optimized process conditions and parameters are listed in Table 1.
EUDRAGIT® L 30 D-55 Spray Suspension Formulation
The pellets were fluidized for 15 min. Microcrystalline cellulose PH has been found to be an effective diluent in extrusion spheronization. Different weight gains of acrylic polymer were applied onto the pellets and evaluated for in vitro dissolution behavior in 0.