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We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. However, we experienced an inconsistent and unpredictable response with alloxan, similar to that discussed by Jain et al.
Alloxan monohydrate (CAS 2244-11-3)
Healthy adult albino rats g and rabbits 1. Alloxan monohydrate Sigma Aldrich, St. Rats were divided into three groups: Rabbits were divided into two groups: Thereafter, FBG was recorded at days 3, 7, 14, 21, 28, and 35 to determine fluctuations in FBG or autoreversal of diabetes.
Monohyydrate Institutional Animal Ethics Committee approved the experimental protocol. Alloxan induced diabetes in All surviving rabbits given alloxan via rapid i.
In diabetic rats and rabbits, random fluctuations in FBG with blood sugar returning to the nondiabetic range at various time periods during the study duration was observed. These fluctuations had no discernible pattern.
These were noted with both low and high doses of alloxan in rats. The rats that were nondiabetic after initial dose of alloxan showed no impairments in oral glucose tolerance test and remained resistant to two subsequent doses of alloxan injected at 1 week interval.
Alloxan: An unpredictable drug for diabetes induction?
These results indicate that the susceptibility to diabetogenic and toxic effects of alloxan differs among animals of the same species. Such unpredictable responses with alloxan have also been reported by authors in the past.
The high degree of resistance to alloxan in rats suggests genetic differences monohydrxte the constitutive ability to dissipate reactive oxygen species responsible for diabetogenic effect of alloxan. This, however, was also associated with a significantly increased mortality. The results of this study suggest the inconsistencies associated monohydtate use of alloxan in induction and maintenance of a stable diabetic state over a period of 1 month in both rats and rabbits.
Thus, with these fluctuations and unpredictable responses at any dose level, we were unable to derive any hypothesis about the hypoglycemic property of test compounds.
We, therefore, agree with the viewpoint of Jain DK et al. This, however, remains contradictory to many studies where alloxan has been successfully used for the same.
National Center for Biotechnology InformationU. Journal List Indian J Pharmacol v. Monika Misra and Umme Aiman. Author information Copyright and License information Disclaimer.
ALLOXAN MONOHYDRATE price,buy ALLOXAN MONOHYDRATE – chemicalbook
This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC.
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Free Radic Biol Med. Effect of rate of injection of alloxan on development of allxan in rabbits.
Alloxan monohydrate | Abcam